600 years ago
1399 

• The Visconti in Milan enacts the first known disinfection by-law for pestilence patients, and 4 years later the first quarantine institution was founded  

200 years ago
1799 

• Valentin Rose Jr. is co-author of the first Prussian medicine book
• Edition of the Manual of pharmaceutical commodities,  a textbook for pharmacognosy in german language
• Edition of the Pharmaopoea Borussica  Edition 1
• Death of Ernst Wilhlem Martiues,  court pharmacist and professor in Erlangen
• Humphry Davy  discovers the anesthetic action of nitrogen sub-oxide (laughing gas), with which Horac Wells in 1844 achieves the first narcosis  

150 years ago
1849 

• Foundation of the "Süddeutschen Apothekersverein"  (Society of Pharmacists in Southern Germany)  

100 years ago
1899 

• Weiss  in Basel discovers that by using china acid in feed the amount of secreted urea decreases. This gives rise to the introduction of some china acid preparations in medicine eg. sidonals (china acid piperazine) and urosins (china acid lithium)
• Heinrich Dreser  adds acetylsalicylic acid to medicines under the name aspirin (acetyl + spir (acic acid) + in) (spiracic = the old name of salicylic)